Analytical Data
-
Gene name
IL-21
- Application
-
Alternative Names
IL-21；Interleukin-21
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9HBE4
-
Expression Region
32-162aa
-
AA Sequence
MQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS
-
Molecular Weight
17 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Interleukin-21 (IL-21) is a crucial cytokine produced by immune cells, particularly T and natural killer (NK) cells, playing a significant role in regulating immune responses. Its involvement in both adaptive and innate immunity has garnered substantial interest in the field of immunology. Research has shown that IL-21 facilitates the proliferation and activation of B cells, enhances antibody production, and promotes the differentiation of T cells into effector and memory subsets, which are vital for effective immune responses. Given its critical functions, IL-21 has been implicated in various diseases, including autoimmune disorders, infections, and malignancies, making it a target for therapeutic intervention. The development of recombinant IL-21 protein has enabled researchers to explore its potential applications in clinical settings, including cancer therapy and vaccination strategies. Recent studies have demonstrated that recombinant IL-21 can enhance anti-tumor immunity, improve vaccine efficacy, and modulate the immune landscape, providing insights into its therapeutic potential. Consequently, IL-21 recombinant protein serves as a valuable tool for understanding immune regulation and developing innovative treatments for immune-related diseases. The ongoing exploration of IL-21's mechanisms and applications holds promise for advancing immunotherapy and improving patient outcomes in various pathological conditions.
