Analytical Data
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基因名
IL-21
- Application
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别名
IL-21；Interleukin-21
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HBE4
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表达区间
32-162aa
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氨基酸序列
MQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS
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分子量
17 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-21 (IL-21) is a crucial cytokine produced by immune cells, particularly T and natural killer (NK) cells, playing a significant role in regulating immune responses. Its involvement in both adaptive and innate immunity has garnered substantial interest in the field of immunology. Research has shown that IL-21 facilitates the proliferation and activation of B cells, enhances antibody production, and promotes the differentiation of T cells into effector and memory subsets, which are vital for effective immune responses. Given its critical functions, IL-21 has been implicated in various diseases, including autoimmune disorders, infections, and malignancies, making it a target for therapeutic intervention. The development of recombinant IL-21 protein has enabled researchers to explore its potential applications in clinical settings, including cancer therapy and vaccination strategies. Recent studies have demonstrated that recombinant IL-21 can enhance anti-tumor immunity, improve vaccine efficacy, and modulate the immune landscape, providing insights into its therapeutic potential. Consequently, IL-21 recombinant protein serves as a valuable tool for understanding immune regulation and developing innovative treatments for immune-related diseases. The ongoing exploration of IL-21's mechanisms and applications holds promise for advancing immunotherapy and improving patient outcomes in various pathological conditions.
