Analytical Data
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Gene name
KRT38
- Application
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Alternative Names
KRT38；HHA8；HKA8；KRTHA8；Keratin. type I cuticular Ha8
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O76015
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Expression Region
2-456aa
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AA Sequence
TSSYSSSSCPLGCTMAPGARNVSVSPIDIGCQPGAEANIAPMCLLANVAHANRVRVGSTPLGRPSLCLPPTCHTACPLPGTCHIPGNIGICGAYGENTLNGHEKETMQFLNDRLANYLEKVRQLEQENAELEATLLERSKCHESTVCPDYQSYFHTIEELQQKILCSKAENARLIVQIDNAKLAADDFRIKLESERSLRQLVEADKCGTQKLLDDATLAKADLEAQQESLKEEQLSLKSNHEQEVKILRSQLGEKLRIELDIEPTIDLNRVLGEMRAQYEAMLETNRQDVEQWFQAQSEGISLQDMSCSEELQCCQSEILELRCTVNALEVERQAQHTLKDCLQNSLCEAEDRFGTELAQMQSLISNVEEQLSEIRADLERQNQEYQVLLDVKTRLENEIATYRNLLESEDCKLPCNPCSTSPSCVTAPCAPRPSCGPCTTCGPTCGASTTGSRF
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Molecular Weight
66.3kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KRT38, a member of the keratin family, is a type of intermediate filament protein predominantly expressed in hair follicles and skin, playing a crucial role in maintaining the structural integrity of epithelial cells. The study of KRT38 recombinant protein has garnered significant interest due to its potential applications in regenerative medicine, dermatology, and hair follicle biology. Understanding the molecular mechanisms underlying KRT38 expression and function can provide insights into various dermatological conditions, including hair loss disorders and skin diseases. Recent advances in recombinant DNA technology enable the production of KRT38 in sufficient quantities for experimental analysis, facilitating investigations into its properties and interactions with other cellular components. By characterizing the structural, biochemical, and functional aspects of KRT38, researchers aim to elucidate its role in keratinocyte differentiation and proliferation, contributing to the broader field of epithelial biology. Furthermore, recombinant KRT38 may serve as a valuable tool for developing novel therapeutic strategies aimed at promoting hair regeneration and improving skin repair mechanisms, addressing significant clinical challenges faced in treating skin and hair disorders. As such, the exploration of KRT38 recombinant protein holds promise for innovative applications in cosmetic and medical fields, paving the way for new treatment modalities in the management of hair and skin-related conditions.
