Analytical Data
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Gene name
ADH7
- Application
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Alternative Names
ADH7；All-trans-retinol dehydrogenase [NAD(+)] ADH7
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P40394
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Expression Region
1-386aa
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AA Sequence
MFAEIQIQDKDRMGTAGKVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICRTDDHVIKGTMVSKFPVIVGHEATGIVESIGEGVTTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGRGVLADGTTRFTCKGKPVHHFMNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGYGAAVKTGKVKPGSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECISPKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALASCHMNYGTSVVVGVPPSAKMLTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEFLAKKFDLDQLITHVLPFKKISEGFELLNSGQSIRTVLTF
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Molecular Weight
43.5kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ADH7, or alcohol dehydrogenase 7, is an important enzyme involved in the metabolism of various alcohols and aldehydes, primarily functioning in the oxidation of retinol (vitamin A) to retinaldehyde. This enzyme plays a crucial role in the liver and the gastrointestinal tract, influencing the detoxification processes and contributing to the regulation of alcohol metabolism. Research on recombinant ADH7 has gained significant attention due to its potential applications in biotechnology and medicine, particularly in understanding its role in different metabolic pathways and its implications in alcohol-related disorders. The ability to produce ADH7 as a recombinant protein allows for detailed studies of its enzymatic properties, substrate specificity, and regulation under various physiological conditions. Moreover, exploring the structural and functional aspects of ADH7 can provide insights into its evolutionary significance and help identify potential therapeutic targets for treating alcohol-induced diseases. The increasing incidence of alcohol-related health issues further emphasizes the need to understand the pharmacogenomics of ADH enzymes, including ADH7, to tailor personalized treatment strategies. By utilizing modern recombinant DNA technology and expression systems, researchers aim to elucidate the intricate mechanisms governing ADH7 function, paving the way for innovative approaches in managing alcohol metabolism and associated pathologies.
