Analytical Data
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基因名
ACTR8
- Application
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别名
ACTR8；ARP8；INO80N；Actin-related Protein 8
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H981-3
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表达区间
1-329aa
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氨基酸序列
MNHKVMILMKMGFSGIVVHQESVCATYGSGLSSTCIVDVGDQKTSVCCVE DGVSHRNTRIFSWNQDISGLQDHEFQIRHPDSPALLYQFRLGDEKLQAPM ALFYPATFGIVGQKMTTLQHRSQGDPEDPHDEHYLLATQSKQEQSAKATA DRKSASKPIGFEGDLRGQSSDLPERLHSQEVDLGSAQGDGLMAGNDSEEA LTALMSRKTAISLFEGKALGLDKAILHSIDCCSSDDTKKKMYSSILVVGG GLMFHKAQEFLQHRILNKMPPSFRRIIENVDVITRPKDMDPRLIAWKGGA VLACLDTTQELWIYQREWQ RFGVRMLRERAAFVW
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分子量
38 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ACTR8, also known as activated Cdc42-associated kinase 8, is a member of the NCK-interacting kinase family that has gained significant attention in cellular and molecular biology research due to its pivotal role in cytoskeletal dynamics and cellular signaling pathways. It is primarily involved in regulating actin filament organization and is implicated in various cellular processes, such as cell migration, adhesion, and morphology. Mutations and alterations in ACTR8 expression levels have been associated with developmental disorders and cancer, highlighting its importance in maintaining cellular homeostasis. Recent studies have focused on understanding the structural characteristics and functional mechanisms of ACTR8, particularly its interactions with GTPases like Cdc42 and its role in the formation of cellular structures like filopodia. Researchers are also investigating the potential of ACTR8 as a therapeutic target, especially in oncology, where its modulation could influence tumor progression and metastasis. As such, the recombinant production of ACTR8 protein has become a critical aspect of research, enabling detailed biochemical assays and structural analyses to decipher the complex regulatory networks it participates in, ultimately advancing our understanding of its biological significance and therapeutic potential.
