Analytical Data
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Gene name
KCNAB2
- Application
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Alternative Names
KCNAB2；KCNA2B；KCNK2；Voltage-gated potassium channel subunit beta-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13303
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Expression Region
1-367aa
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AA Sequence
MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPYSKKDYRS
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Molecular Weight
57.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KCNAB2, a subunit of the voltage-gated potassium channel, plays a crucial role in modulating the electrical activity of neurons and other excitable cells. The protein is essential for the proper functioning of these channels, as it influences their kinetics, voltage sensitivity, and overall channel composition. Research into KCNAB2 has gained momentum due to its involvement in various physiological processes and potential link to pathophysiological conditions, such as epilepsy, cardiac arrhythmias, and other neurological disorders. Recent advancements in recombinant protein technology have made it possible to produce KCNAB2 in sufficient quantities for detailed structural and functional analyses. This has enabled scientists to investigate its interactions with other channel subunits and regulatory proteins, enhancing our understanding of channel assembly, trafficking, and gating mechanisms. Moreover, identifying the specific role of KCNAB2 in disease models could pave the way for targeted therapies aimed at restoring normal channel function. As the demand for efficient treatments for related disorders grows, KCNAB2 remains a promising candidate for further exploration, reflecting its significance not only in basic neuroscience but also in clinical research. The ongoing studies aim to elucidate the molecular mechanisms underlying KCNAB2's function and its potential as a therapeutic target. Through comprehensive investigations, we anticipate gaining insights into its diverse roles in cellular excitability and potential implications in health and disease.
