Analytical Data
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基因名
IL13
- Application
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别名
IL13；NC30；Interleukin-13
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P35225
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表达区间
25-146aa
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氨基酸序列
LTCLGGFASP GPVPPSTALR ELIEELVNIT QNQKAPLCNG SMVWSINLTA GMYCAALESL INVSGCSAIE KTQRMLSGFC PHKVSAGQFS SLHVRDTKIE VAQFVKDLLL HLKKLFREGR FN
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分子量
13 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-13 (IL-13) is a pivotal cytokine produced primarily by Th2 cells, playing a crucial role in mediating immune responses, particularly in allergic reactions and asthma. It is a key regulator of inflammation, influencing the activation and differentiation of various immune cells. IL-13 has been implicated in the pathogenesis of numerous diseases, including atopic dermatitis, chronic rhinosinusitis, and fibrotic disorders, making it a target for therapeutic interventions. The study of recombinant IL-13 protein has gained significant attention due to its potential in elucidating the mechanisms of Th2-mediated responses and its application in developing novel treatments. Researchers focus on understanding the structure-function relationship of IL-13 to design specific inhibitors or monoclonal antibodies that could attenuate its activity. Moreover, recombinant IL-13 is utilized in experimental models to better comprehend its role in immune regulation and disease progression. The ongoing research aims to harness the therapeutic potential of IL-13 modulation, paving the way for innovative strategies in managing allergic diseases and related conditions. By exploring the intricacies of IL-13 signaling pathways, scientists hope to identify biomarkers for disease prognosis and progression, ultimately leading to improved clinical outcomes.
