Analytical Data
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Gene name
FANCC
- Application
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Alternative Names
FANCC；FAC；FACC；Fanconi anemia group C Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q00597
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Expression Region
1-558aa
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AA Sequence
MAQDSVDLSCDYQFWMQKLSVWDQASTLETQQDTCLHVAQFQEFLRKMYEALKEMDSNTVIERFPTIGQLLAKACWNPFILAYDESQKILIWCLCCLINKEPQNSGQSKLNSWIQGVLSHILSALRFDKEVALFTQGLGYAPIDYYPGLLKNMVLSLASELRENHLNGFNTQRRMAPERVASLSRVCVPLITLTDVDPLVEALLICHGREPQEILQPEFFEAVNEAILLKKISLPMSAVVCLWLRHLPSLEKAMLHLFEKLISSERNCLRRIECFIKDSSLPQAACHPAIFRVVDEMFRCALLETDGALEIIATIQVFTQCFVEALEKASKQLRFALKTYFPYTSPSLAMVLLQDPQDIPRGHWLQTLKHISELLREAVEDQTHGSCGGPFESWFLFIHFGGWAEMVAEQLLMSAAEPPTALLWLLAFYYGPRDGRQQRAQTMVQVKAVLGHLLAMSRSSSLSAQDLQTVAGQGTDTDLRAPAQQLIRHLLLNFLLWAPGGHTIAWDVITLMAHTAEITHEIIGFLDQTLYRWNRLGIESPRSEKLARELLKELRTQV
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Molecular Weight
79.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FANCC, a member of the Fanconi anemia (FA) pathway, is crucial for DNA repair and maintains genomic stability. Mutations in the FANCC gene are associated with Fanconi anemia, a rare genetic disorder characterized by bone marrow failure, increased cancer susceptibility, and various physical abnormalities. Research on FANCC recombinant protein has gained importance in understanding the molecular mechanisms underlying FA and its role in DNA damage response. Recombinant FANCC protein can be produced using various expression systems, enabling researchers to study its interactions with other FA proteins and its function in DNA repair pathways. Additionally, investigating the structural and functional properties of FANCC may provide insights into the development of targeted therapies for FA patients. Understanding FANCC's role in cellular response to DNA damage could lead to potential advancements in cancer therapy, as targeting these pathways can enhance the efficacy of existing treatments. Furthermore, studying FANCC recombinants aids in exploring the biochemical functions of related proteins within the FA complex, contributing to the broader understanding of the mechanisms of genomic integrity and the etiology of related disorders. Overall, FANCC recombinant protein research is pivotal for uncovering critical insights into the FA pathway, its involvement in DNA repair mechanisms, and the potential therapeutic applications for conditions arising from FA-related mutations.
