Analytical Data
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Gene name
Fcmr
- Application
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Alternative Names
Fcmr；FAIM3；TOSO；Immunoglobulin mu Fc receptor
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O60667
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Expression Region
1-390aa
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AA Sequence
MDFWLWPLYFLPVSGALRILPEVKVEGELGGSVTIKCPLPEMHVRIYLCREMAGSGTCGTVVSTTNFIKAEYKGRVTLKQYPRKNLFLVEVTQLTESDSGVYACGAGMNTDRGKTQKVTLNVHSEYEPSWEEQPMPETPKWFHLPYLFQMPAYASSSKFVTRVTTPAQRGKVPPVHHSSPTTQITHRPRVSRASSVAGDKPRTFLPSTTASKISALEGLLKPQTPSYNHHTRLHRQRALDYGSQSGREGQGFHILIPTILGLFLLALLGLVVKRAVERRKALSRRARRLAVRMRALESSQRPRGSPRPRSQNNIYSACPRRARGADAAGTGEAPVPGPGAPLPPAPLQVSESPWLHAPSLKTSCEYVSLYHQPAAMMEDSDSDDYINVPA
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Molecular Weight
43.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FCMR (Fc receptor-like molecule) is an intriguing receptor that plays a crucial role in the immune response, particularly in the regulation of antibody-dependent cellular cytotoxicity (ADCC) and immune homeostasis. As a member of the Fc receptor family, FCMR interacts specifically with IgM antibodies, facilitating the initiation of innate immune responses. Recent studies have revealed that FCMR is expressed on various immune cells, including B cells and dendritic cells, indicating its potential involvement in modulating adaptive immunity. The reconstitution of FCMR as a recombinant protein holds significant promise for deeper investigations into its functional roles and mechanisms of action. By generating recombinant FCMR, researchers are able to study its binding interactions with IgM and elucidate the downstream signaling pathways activated upon receptor engagement. This research is essential for understanding how FCMR influences immune responses in different physiological and pathological contexts, such as infections, autoimmunity, and cancer. Moreover, insights gained from the study of FCMR may pave the way for novel therapeutic approaches that harness its unique properties to modulate immune responses, providing new strategies for intervention in diseases where the immune system plays a critical role. Overall, the study of FCMR recombinant protein is a promising area of research with potential implications for enhancing our understanding of immune regulation and developing new immunotherapeutic strategies.
