Analytical Data
-
基因名
ESR2
- Application
-
别名
ESR2；ESTRB；NR3A2；Estrogen receptor beta
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q92731
-
表达区间
2-530aa
-
氨基酸序列
DIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
-
分子量
61.1 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of ESR2, or Estrogen Receptor Beta, recombinant proteins has garnered significant attention in the fields of molecular biology and pharmacology due to their pivotal role in various physiological processes and disease states. ESR2 is part of the nuclear hormone receptor superfamily and is known to mediate the biological effects of estrogens, which are crucial for the regulation of reproductive functions, bone density, cardiovascular health, and cognitive functions. Unlike its counterpart, Estrogen Receptor Alpha (ESR1), ESR2 has distinct tissue distribution and functional implications, making it a focal point in understanding estrogen signaling pathways and their impact on health. Research has indicated that ESR2 plays a protective role against various cancers, cardiovascular diseases, and metabolic disorders. Recombinant proteins of ESR2 allow for detailed investigations into its structure, function, and interaction with ligands and co-regulators. Utilizing such proteins in experimental models enables researchers to elucidate the receptor's mechanisms of action, examine the effects of estrogenic compounds, and explore potential therapeutic applications, particularly in hormone-related cancers. By advancing our understanding of ESR2 through recombinant technologies, we can potentially develop targeted interventions and improve clinical outcomes in diseases associated with estrogen dysregulation. Hence, the research on ESR2 recombinant proteins is essential for advancing both basic science and therapeutic strategies.
