Analytical Data
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Gene name
ESR2
- Application
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Alternative Names
ESR2；ESTRB；NR3A2；Estrogen receptor beta
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92731
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Expression Region
2-530aa
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AA Sequence
DIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
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Molecular Weight
61.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of ESR2, or Estrogen Receptor Beta, recombinant proteins has garnered significant attention in the fields of molecular biology and pharmacology due to their pivotal role in various physiological processes and disease states. ESR2 is part of the nuclear hormone receptor superfamily and is known to mediate the biological effects of estrogens, which are crucial for the regulation of reproductive functions, bone density, cardiovascular health, and cognitive functions. Unlike its counterpart, Estrogen Receptor Alpha (ESR1), ESR2 has distinct tissue distribution and functional implications, making it a focal point in understanding estrogen signaling pathways and their impact on health. Research has indicated that ESR2 plays a protective role against various cancers, cardiovascular diseases, and metabolic disorders. Recombinant proteins of ESR2 allow for detailed investigations into its structure, function, and interaction with ligands and co-regulators. Utilizing such proteins in experimental models enables researchers to elucidate the receptor's mechanisms of action, examine the effects of estrogenic compounds, and explore potential therapeutic applications, particularly in hormone-related cancers. By advancing our understanding of ESR2 through recombinant technologies, we can potentially develop targeted interventions and improve clinical outcomes in diseases associated with estrogen dysregulation. Hence, the research on ESR2 recombinant proteins is essential for advancing both basic science and therapeutic strategies.
