Analytical Data
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Gene name
MERTK
- Application
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Alternative Names
MERTK；MER；Tyrosine-Protein kinase Mer
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q12866
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Expression Region
578-872aa
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AA Sequence
EDV VIDRNLLILG KILGEGEFGS VMEGNLKQED GTSLKVAVKT MKLDNSSQRE IEEFLSEAAC MKDFSHPNVI RLLGVCIEMS SQGIPKPMVI LPFMKYGDLH TYLLYSRLET GPKHIPLQTL LKFMVDISLG MEYLSNRNFL HRDLAARNCM LRDDMTVCVA DFGLSKKIYS GDYYRQGRIA KMPVKWIAIE SLADRVYTSK SDVWAFGVTM WEIATRGMTP YPGVQNHEMY DYLLHGHRLK QPEDCLDELY EIMYSCWRTD PLDRPTFSVL RLQLEKLLES LPDVRNQADV IY
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Molecular Weight
58 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MERTK (Mer Tyrosine Kinase) is a receptor tyrosine kinase that plays a crucial role in various biological processes, including cell differentiation, immune response, and the clearance of apoptotic cells. Dysregulation of MERTK signaling has been implicated in several diseases, particularly in cancer and autoimmune disorders. The interest in MERTK as a therapeutic target has grown due to its involvement in tumor progression and immune evasion, making it a potential candidate for cancer immunotherapy. Research has shown that MERTK can modulate the immune response by facilitating the uptake of apoptotic cells, thereby promoting an anti-inflammatory environment. Recombinant MERTK proteins have been developed to study its structure, function, and interaction with other molecules. These proteins serve as valuable tools for understanding the mechanisms underlying MERTK signaling and its role in disease. Additionally, the development of MERTK-targeted therapies, including monoclonal antibodies and small molecule inhibitors, is being explored in preclinical and clinical settings. As such, the study of recombinant MERTK proteins is essential for elucidating the pathways involved in its signaling and for advancing potential therapeutic strategies aimed at modulating MERTK activity in various pathological conditions.
