Analytical Data
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Gene name
CYP2C8
- Application
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Alternative Names
CYP2C8；Cytochrome P450 2C8
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P10632
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Expression Region
27-490aa
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AA Sequence
RKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV
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Molecular Weight
60.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CYP2C8 is a member of the cytochrome P450 superfamily of enzymes, which play a crucial role in the metabolism of various drugs and endogenous compounds. The significance of CYP2C8 is particularly highlighted in pharmacogenomics, where genetic variations in this enzyme can influence drug metabolism and, consequently, therapeutic outcomes. It is known to be involved in the biotransformation of clinically important medications, such as paclitaxel and repaglinide, making it critical for individualized medicine. Research into the recombinant expression of CYP2C8 is essential for elucidating its function, substrate specificity, and interaction with other metabolic pathways. By producing recombinant CYP2C8 proteins, researchers can study the enzyme's kinetic properties, identify potential drug-drug interactions, and improve the understanding of interindividual variability in drug responses. Furthermore, elucidating the structure and function of CYP2C8 through recombinant methodologies can provide insights into the design of novel therapeutic agents and the development of strategies to mitigate adverse drug reactions. Overall, the study of CYP2C8 recombinant proteins is vital for advancing pharmacological research, optimizing drug therapy, and fostering the development of precision medicine approaches in healthcare.
