Analytical Data
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Gene name
CXCL10
- Application
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Alternative Names
CXCL10；INP10；SCYB10；C-X-C motif chemokine 10
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P02778
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Expression Region
22-98aa
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AA Sequence
VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP
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Molecular Weight
9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CXCL10, a chemokine belonging to the CXC family, plays a critical role in immune response and inflammation by attracting immune cells to sites of infection or injury. Its receptor, CXCR3, is predominantly expressed on T cells, making CXCL10 essential for T cell migration and activation, particularly in viral infections and autoimmune diseases. Research has demonstrated that CXCL10 is involved in various pathological conditions, including cancer, chronic inflammatory diseases, and viral infections, highlighting its potential as a therapeutic target. Recent studies have focused on the production and characterization of recombinant CXCL10 to better understand its biological functions and therapeutic applications. By expressing CXCL10 in a recombinant system, researchers can obtain large quantities of the protein for detailed analysis, including its interaction with receptors and effects on immune cell behavior. Furthermore, understanding the structure-function relationship of CXCL10 could lead to the development of novel drugs or treatments that modulate its activity, offering new strategies for managing diseases characterized by dysregulated immune responses. The study of CXCL10 not only enhances our understanding of immune mechanisms but also paves the way for innovative therapeutic approaches, making it a significant focus in immunology and translational medicine.
