Analytical Data
-
基因名
C14orf126
- Application
-
别名
DTD2; C14orf126D-aminoacyl-tRNA deacylase 2; EC 3.1.1.96; Animalia-specific tRNA deacylase; ATD; D-tyrosyl-tRNA(Tyr) deacylase 2; L-alanyl-tRNA deacylase
-
种属
Human
-
表达系统
E. coli
-
标签
GST-tag at N-terminal
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q96FN9
-
表达区间
1-168aa
-
氨基酸序列
MAEGSRIPQARALLQQCLHARLQIRPADGDVAAQWVEVQRGLVIYVCFFKGADKELLPKMVNTLLNVKLSETENGKHVSILDLPGNILIIPQATLGGRLKGRNMQYHSNSGKEEGFELYSQFVTLCEKEVAANSKCAEARVVVEHGTYGNRQVLKLDTNGPFTHLIEF
-
分子量
45.1 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
C14orf126, also known as PNKP (polynucleotide kinase/phosphatase), plays a critical role in DNA repair pathways, particularly in the maintenance of genomic stability. Its gene is located on chromosome 14 and is involved in the repair of single-strand breaks in DNA through its enzymatic activities. Deficiencies in C14orf126 have been associated with various diseases, including cancer, where impaired DNA repair mechanisms can lead to increased mutagenesis and tumorigenesis. Recent studies have highlighted the importance of C14orf126 in neuronal health, with mutations linked to neurodegenerative disorders, underscoring its relevance in both cancer biology and neurobiology. The recombinant protein of C14orf126 is being explored to better understand its biochemical functions and interactions within the DNA repair machinery. Structural and functional studies of this protein could provide insights into its mechanism of action, potential regulatory pathways, and its role in cellular responses to DNA damage. Furthermore, understanding C14orf126's interactions with other key proteins may uncover new therapeutic targets for enhancing DNA repair in diseased cells, offering a promising avenue for cancer treatment and neuroprotection strategies. Overall, C14orf126 represents a significant focal point in the study of DNA damage response and repair, making it a vital subject for ongoing research in genomics and molecular biology.
