Analytical Data
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基因名
Tie1
- Application
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别名
Tie1；TIE；Tyrosine-Protein kinase receptor Tie-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P35590
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表达区间
22-760aa
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氨基酸序列
AVDLTLLANL RLTDPQRFFL TCVSGEAGAG RGSDAWGPPL LLEKDDRIVR TPPGPPLRLA RNGSHQVTLR GFSKPSDLVG VFSCVGGAGA RRTRVIYVHN SPGAHLLPDK VTHTVNKGDT AVLSARVHKE KQTDVIWKSN GSYFYTLDWH EAQDGRFLLQ LPNVQPPSSG IYSATYLEAS PLGSAFFRLI VRGCGAGRWG PGCTKECPGC LHGGVCHDHD GECVCPPGFT GTRCEQACRE GRFGQSCQEQ CPGISGCRGL TFCLPDPYGC SCGSGWRGSQ CQEACAPGHF GADCRLQCQC QNGGTCDRFS GCVCPSGWHG VHCEKSDRIP QILNMASELE FNLETMPRIN CAAAGNPFPV RGSIELRKPD GTVLLSTKAI VEPEKTTAEF EVPRLVLADS GFWECRVSTS GGQDSRRFKV NVKVPPVPLA APRLLTKQSR QLVVSPLVSF SGDGPISTVR LHYRPQDSTM DWSTIVVDPS ENVTLMNLRP KTGYSVRVQL SRPGEGGEGA WGPPTLMTTD CPEPLLQPWL EGWHVEGTDR LRVSWSLPLV PGPLVGDGFL LRLWDGTRGQ ERRENVSSPQ ARTALLTGLT PGTHYQLDVQ LYHCTLLGPA SPPAHVLLPP SGPPAPRHLH AQALSDSEIQ LTWKHPEALP GPISKYVVEV QVAGGAGDPL WIDVDRPEET STIIRGLNAS TRYLFRMRAS IQGLGDWSNT VEESTLGNGL QAEGPVQESR AAEEGLDQQV DHHHHHH
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分子量
81 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Tie1 is a receptor tyrosine kinase that plays a pivotal role in the regulation of angiogenesis, vascular stability, and endothelial cell function. It is primarily expressed in endothelial cells and is thought to be crucial for the development and maintenance of the vasculature. Research on Tie1 has gained significance due to its potential implications in various pathological conditions, including cancer, cardiovascular diseases, and inflammatory disorders. The involvement of Tie1 in modulating the endothelial barrier and its interactions with other vascular growth factors, such as VEGF, have made it a target of interest for therapeutic interventions. Moreover, the elucidation of Tie1's signaling mechanisms may provide deeper insights into the processes governing blood vessel formation and remodeling. As a result, the production of recombinant Tie1 protein has become essential for in vitro and in vivo studies aiming to unravel its biological functions and therapeutic applications. Investigating Tie1 through recombinant protein technology allows researchers to explore its effects on endothelial cell behavior, contribute to drug discovery efforts, and assess its potential as a biomarker in various diseases. Overall, the study of Tie1 and its recombinant forms stands at the intersection of developmental biology and translational medicine, highlighting its importance in understanding vascular biology and developing innovative treatment strategies.
