Analytical Data
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Gene name
PRKACG
- Application
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Alternative Names
cAMP-dependent protein kinase catalytic subunit gamma; KAPCG_HUMAN; KAPG ; PKA C gamma; PKA C-gamma; PKACg; PRKACG; Protein kinase cAMP dependent catalytic gamma; Serine (threonine) protein kinase
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P22612
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Expression Region
2-351 aa
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AA Sequence
GNAPAKKDT EQEESVNEFL AKARGDFLYR WGNPAQNTAS SDQFERLRTL GMGSFGRVML VRHQETGGHY AMKILNKQKV VKMKQVEHIL NEKRILQAID FPFLVKLQFS FKDNSYLYLV MEYVPGGEMF SRLQRVGRFS EPHACFYAAQ VVLAVQYLHS LDLIHRDLKP ENLLIDQQGY LQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAVGFPPFY ADQPIQIYEK IVSGRVRFPS KLSSDLKHLL RSLLQVDLTK RFGNLRNGVG DIKNHKWFAT TSWIAIYEKK VEAPFIPKYT GPGDASNFDD YEEEELRISI NEKCAKEFSE F
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Molecular Weight
40.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PRKACG, or Protein Kinase A Catalytic Subunit Gamma, is a vital component of the Protein Kinase A (PKA) signaling pathway, which plays a critical role in various cellular processes, including metabolism, gene expression, and cell proliferation. Research on PRKACG has gained momentum due to its involvement in cancer biology and other diseases. Abnormal regulation of PKA can lead to significant pathological consequences; thus, studying PRKACG may provide insights into therapeutic targets for cancer treatment and other disorders linked to aberrant signaling pathways. Recent advancements in recombinant protein technology have enabled researchers to produce PRKACG in a purified form, facilitating detailed studies of its structure, function, and interactions with regulatory subunits and substrates. Understanding the biochemical properties and regulatory mechanisms of PRKACG at a molecular level can illuminate its role in health and disease, potentially leading to novel strategies for drug development. The exploration of PRKACG also offers opportunities to investigate its functional variations across different tissues and species, enhancing our knowledge of the evolutionary conservation of PKA signaling and its implications for cellular management and response to external stimuli.
