Analytical Data
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基因名
BCAS1
- Application
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别名
BCAS1；AIBC1；NABC1；Breast carcinoma-amplified sequence 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75363
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表达区间
1-584aa
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氨基酸序列
MGNQMSVPQRVEDQENEPEAETYQDNASALNGVPVVVSTHTVQHLEEVDLGISVKTDNVATSSPETTEISAVADANGKNLGKEAKPEAPAAKSRFFLMLSRPVPGRTGDQAADSSLGSVKLDVSSNKAPANKDPSESWTLPVAAGPGQDTDKTPGHAPAQDKVLSAARDPTLLPPETGGAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIVDGKEKEGQELGTADCSVPGDPEGLETAKDDSQAAAIAENNNSIMSFFKTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKREESKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSDSTEKTITPPEPEPTGAPQKGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQNGDKLQKRPEKRQQSLGGFFKGLGPKRMLDAQVQTDPVSIGPVGKSK
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分子量
63.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BCAS1 (Breast Cancer Associated Antigen 1) is a nuclear protein originally identified for its overexpression in breast cancer tissues. Emerging evidence suggests that BCAS1 plays a significant role in tumorigenesis, particularly in breast cancer, by influencing cell proliferation, apoptosis, and DNA repair mechanisms. Its involvement in various cellular processes, including transcriptional regulation and chromatin remodeling, highlights its potential as a key player in cancer biology. Additionally, BCAS1 has been linked to the modulation of the estrogen receptor pathway, further implicating it in breast cancer progression and response to hormone therapies. Given its specific expression patterns and functional relevance, BCAS1 has garnered attention as a potential biomarker for breast cancer diagnosis and prognosis, as well as a candidate for targeted therapeutic strategies. Recent research efforts focus on the production and characterization of recombinant BCAS1 proteins to elucidate their functional roles at the molecular level and to explore their potential as therapeutic targets. Understanding the mechanistic pathways involving BCAS1 could lead to novel interventions in breast cancer treatment, providing insights into the intricate network of molecular interactions that drive tumor development and progression. This research is vital for advancing personalized medicine approaches and improving outcomes for patients with breast cancer, highlighting BCAS1's importance in the field of cancer research and therapeutic development.
