Analytical Data
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基因名
AP1S3
- Application
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别名
AP1S3；AP-1 complex subunit sigma-3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96PC3
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表达区间
1-104aa
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氨基酸序列
MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNTWPFARA
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分子量
39.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AP1S3, a component of the adaptor protein complex 1 (AP-1), plays a critical role in intracellular transport and sorting of transmembrane proteins. As a key player in the clathrin-mediated endocytic pathway, AP1S3 is involved in the retrieval of proteins from the trans-Golgi network to lysosomes, which is essential for maintaining cellular homeostasis and function. Dysregulation of AP1S3 has been linked to various diseases, including metabolic disorders and cancer, making it a significant focus of biomedical research. Recent studies have highlighted its potential role in modulating signaling pathways, influencing cell proliferation, and apoptosis. Understanding the structural and functional characteristics of AP1S3 can provide insights into its mechanisms in health and disease. Furthermore, research into recombinant AP1S3 protein offers opportunities for developing therapeutic strategies targeting its function, contributing to the broader field of molecular biology and biotechnology. Investigating AP1S3 can unravel novel interactions and pathways, contributing to our knowledge of cellular transport mechanisms and their implications in human health.
