Analytical Data
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Gene name
CFHR2
- Application
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Alternative Names
CFHR2；CFHL2；FHR2；HFL3；Complement factor H-related Protein 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P36980
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Expression Region
19-270aa
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AA Sequence
EA MFCDFPKINH GILYDEEKYK PFSQVPTGEV FYYSCEYNFV SPSKSFWTRI TCAEEGWSPT PKCLRLCFFP FVENGHSESS GQTHLEGDTV QIICNTGYRL QNNENNISCV ERGWSTPPKC RSTISAEKCG PPPPIDNGDI TSFLLSVYAP GSSVEYQCQN LYQLEGNNQI TCRNGQWSEP PKCLDPCVIS QEIMEKYNIK LKWTNQQKLY SRTGDIVEFV CKSGYHPTKS HSFRAMCQNG KLVYPSCEEK
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CFHR2 (Complement Factor H-Related Protein 2) is part of a group of proteins that play a critical role in the regulation of the complement system, which is an essential part of the immune response. Research into CFHR2 has gained significant attention due to its potential involvement in various diseases, including age-related macular degeneration (AMD) and atypical hemolytic uremic syndrome (aHUS). These conditions are linked to dysregulation of the complement system, leading to inflammation and tissue damage. CFHR2 shares structural similarities with complement factor H, a key regulator of the complement pathway, suggesting that it may have functional properties that influence immune responses and inflammation. Studying the recombinant form of CFHR2 allows researchers to investigate its biochemical properties, physiological roles, and potential implications in disease mechanisms. Understanding how CFHR2 interacts with other complement components and its impact on the immune system could provide insights into new therapeutic strategies for complement-mediated diseases. Additionally, the exploration of CFHR2 could lead to the development of biomarkers for early disease detection and assessment of disease progression, making it a significant focus in immunological research.
