Analytical Data
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Gene name
PQLC2
- Application
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Alternative Names
SLC66A1; PQLC2; Lysosomal amino acid transporter 1 homolog; PQ-loop repeat-containing protein 2; Solute carrier family 66 member 1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6ZP29
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Expression Region
1-226 aa
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AA Sequence
MDQALSLWFLLGWIGGDSCNLIGSFLADQLPLQTYTAVYYVLADLVMLTLYFYYKFRTRPSLLSAPINSVLLFLMGMACATPLLSAAGPVAAPREAFRGRALLSVESGSKPFTRQEVIGFVIGSISSVLYLLSRLPQIRTNFLRKSTQGISYSLFALVMLGNTLYGLSVLLKNPEEGQSEGSYLLHHLPWLVGSLGVLLLDTIISIQFLVYRRSTAASELEPLLPS
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Molecular Weight
51.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PQLC2 (Pseudomonas putida quinone permease-like 2) is a member of the solute carrier family and has garnered significant attention due to its potential roles in various physiological and pathological processes. It is primarily identified as a membrane protein with a unique function in transporting specific metabolites across cellular membranes. Recent studies suggest that PQLC2 is involved in the response to cellular stress and plays a role in maintaining cellular homeostasis. Given the increasing incidence of metabolic disorders and the need for novel therapeutic strategies, understanding the functional mechanisms of PQLC2 and its interactions with other molecular targets is essential. Research has also highlighted its potential implications in cancer biology, as altered expression of PQLC2 may influence tumor progression and drug resistance. Therefore, the recombinant expression of PQLC2 in various model systems is critical for elucidating its structure-function relationships and for developing targeted interventions. By producing and characterizing recombinant PQLC2, researchers aim to shed light on its transport mechanisms and to explore its potential as a biomarker or therapeutic target in metabolic and oncological diseases. This research underlines the importance of PQLC2 in both basic and translational science, paving the way for future investigations into its pharmacological significance and therapeutic applications.
