Analytical Data
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基因名
STEAP1
- Application
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别名
STEAP1;PRSS24;STEAP;STEAP1 Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UHE8
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表达区间
1-339aa
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氨基酸序列
MESRKDITNQEELWKMKPRRNLEEDDYLHKDTGETSMLKRPVLLHLHQTAHADEFDCPSELQHTQELFPQWHLPIKIAAIIASLTFLYTLLREVIHPLATSHQQYFYKIPILVINKVLPMVSITLLALVYLPGVIAAIVQLHNGTKYKKFPHWLDKWMLTRKQFGLLSFFFAVLHAIYSLSYPMRRSYRYKLLNWAYQQVQQNKEDAWIEHDVWRMEIYVSLGIVGLAILALLAVTSIPSVSDSLTWREFHYIQSKLGIVSLLLGTIHALIFAWNKWIDIKQFVWYTPPTFMIAVFLPIVVLIFKSILFLPCLRKKILKIRHGWEDVTKINKTEICSQL
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分子量
41.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
STEAP1 (six-transmembrane epithelial antigen of prostate 1) is an integral membrane protein that has gained significant interest due to its prominent role in cancer biology, particularly in prostate cancer. As a member of the STEAP family, STEAP1 is characterized by its six transmembrane domains and is primarily expressed in prostate tissues, making it a potential biomarker for prostate cancer diagnosis and therapy. Research has revealed that STEAP1 is involved in various cellular processes, including iron metabolism and cellular differentiation, which are crucial for tumor progression. The overexpression of STEAP1 in malignant tissues compared to normal epithelial cells suggests its potential as a therapeutic target. Recombinant STEAP1 proteins have been developed for further investigation into its biological functions, interactions, and potential as a target for immunotherapy. Studies on STEAP1 recombinant proteins have focused on understanding its structure-function relationship and elucidating mechanisms of action in cancer cells. These efforts aim to pave the way for novel therapeutic strategies, including monoclonal antibodies or vaccine-based approaches that could lead to more effective treatments for prostate cancer. Additionally, the study of STEAP1 offers insights into potential pathways that could be exploited in targeting other malignancies where STEAP proteins are implicated, thus broadening the scope of applications for STEAP1-related research. Overall, the investigation of recombinant STEAP1 proteins stands at the intersection of cancer biology and therapeutic innovation, highlighting its significance in the ongoing effort to develop targeted cancer therapies.












