Analytical Data
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基因名
C5AR2
- Application
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别名
C5AR2；C5L2；GPR77；C5a anaphylatoxin chemotactic receptor 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9P296
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表达区间
1-337aa
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氨基酸序列
MGNDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLRVAPLPLYAAIFLVGVPGNAMVAWVAGKVARRRVGATWLLHLAVADLLCCLSLPILAVPIARGGHWPYGAVGCRALPSIILLTMYASVLLLAALSADLCFLALGPAWWSTVQRACGVQVACGAAWTLALLLTVPSAIYRRLHQEHFPARLQCVVDYGGSSSTENAVTAIRFLFGFLGPLVAVASCHSALLCWAARRCRPLGTAIVVGFFVCWAPYHLLGLVLTVAAPNSALLARALRAEPLIVGLALAHSCLNPMLFLYFGRAQLRRSLPAACHWALRESQGQDESVDSKKSTSHDLVSEMEV
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分子量
36.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
C5a receptor 2 (C5ar2) is a G protein-coupled receptor that plays a critical role in the immune response, particularly in the regulation of inflammation. It is a receptor for the complement component C5a, which is involved in the recruitment and activation of immune cells during inflammatory responses. Research into C5ar2 is significant as it has been implicated in various pathological conditions, including autoimmune diseases, sepsis, and cancer. Understanding the signaling pathways and functional mechanisms of C5ar2 can reveal insights into its role in modulating immune responses, potentially leading to novel therapeutic approaches for inflammatory diseases. Moreover, C5ar2's interaction with other receptors and signaling molecules highlights its complexity in immune modulation. Recent studies focusing on the structural and functional characterization of C5ar2 have utilized recombinant protein techniques to produce the receptor in a controlled environment, allowing for detailed biochemical and biophysical analysis. This research aims to elucidate C5ar2's role in immune system dynamics and its potential as a target for drug development. By exploring the receptor's pharmacology and its effects on immune cell behavior, scientists hope to bridge the gap between basic research and clinical applications, ultimately enhancing the understanding and treatment of diseases where inflammation plays a pivotal role.
