Analytical Data
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Gene name
PPP4R1L
- Application
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Alternative Names
PPP4R1L; C20orf192; PRO1085; Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9P1A2
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Expression Region
1-415 aa
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AA Sequence
MAEIPLYFVD LQDDLDDYGF EDYGTDCDNM RVTAFLDIPG QDNLPPLTRL EKYAFSENTF NRQIIARGLL DIFRDFGNNE EDFLTVMEIV VRLSEDAEPT VRTELMEQIP PIAIFLQENR SNFPVVLSEY LIPIVVRYLT DPNNQIICKM ASMLSKSTVE RLLLPRFCEL CGDRKLFQVR KVCAANFGDI CHAVGQEATE KFLIPKFFEL CSDAVWGMRK ACAECFTAVS HSSSPGVRRT QLFPLFIRLV SDPCRWVHQA AFQSLGPFTS TFANPSRAGL YLREDGALSI WPLTQDLDSG FASGSPAPSS GGNTSPASLT RSAKPVRSEP ELPVEGTSAK TSDCPHSSSS SDGPAESPVE SCVSAGAEWT RVSPETSACS KLSDMNDLPI SSYPGSDSWA CPGNTEDVFS HFLYW
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Molecular Weight
45.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PPP4R1L, a regulatory subunit of protein phosphatase 4 (PP4), plays a vital role in various cellular processes, including cell cycle regulation and DNA repair. As a member of the PPP4R family, PPP4R1L has garnered attention due to its involvement in modulating the activity of PP4, which is crucial for dephosphorylating specific substrates that influence cellular signaling pathways. Recent studies have suggested that dysregulation of PP4 and its regulatory subunits may contribute to oncogenesis and other diseases. Understanding the structure and function of PPP4R1L is essential for elucidating its role in these pathological processes. Recombining PPP4R1L allows researchers to investigate its biochemical properties, impacts on cellular functions, and potential therapeutic applications. Investigating the dynamics of PPP4R1L in relation to PP4 activity could provide insights into disease mechanisms and highlight new targets for drug development. Consequently, research on recombinant PPP4R1L not only contributes to our fundamental understanding of cell signaling but also opens avenues for potential interventions in cancer and other disorders associated with aberrant phosphatase activity.
