Analytical Data
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基因名
APH1a
- Application
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别名
APH1a；PSF；Gamma-secretase subunit APH-1A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96BI3
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表达区间
235-265aa
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氨基酸序列
SLRSIQRSLLCRRQEDSRVMVYSALRIPPED
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分子量
11.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
APH1a (anterior pharynx 1a) is a crucial component of the gamma-secretase complex, a multifunctional protease integral to the regulation of various cellular processes, including the cleavage of type I membrane proteins. Research on APH1a has gained prominence due to its pivotal role in Alzheimer's disease, where dysregulation of gamma-secretase activity leads to the aberrant processing of the amyloid precursor protein (APP) and the consequent accumulation of amyloid-beta peptides, key pathological hallmarks of the disease. Understanding the structure, function, and molecular interactions of APH1a is vital for elucidating its contributions to gamma-secretase activity and its implications in neurodegenerative disorders. Genetic studies have identified APH1a as a potential genetic risk factor for Alzheimer's disease, bolstering interest in its recombinant protein form for further investigations. The study of APH1a recombinant protein provides insights into its biochemistry, interaction partners, and regulatory mechanisms, paving the way for developing targeted therapeutic strategies that could mitigate the effects of gamma-secretase dysregulation in Alzheimer's and possibly other diseases. Through biochemical assays, structural biology, and cell-based models, researchers aim to delineate the functional roles of APH1a and enhance our understanding of its contribution to cellular homeostasis and disease pathology.
