Analytical Data
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Gene name
HTR3D
- Application
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Alternative Names
HTR3D；5-hydroxytryptamine receptor 3D
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q70Z44
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Expression Region
221-454aa
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AA Sequence
VAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVAPLALMQTPLPAGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLWNT
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Molecular Weight
41.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HTR3D, a member of the 5-HT receptor family, plays a crucial role in neurotransmission and various physiological functions, including mood regulation and cognition. Research on recombinant HTR3D proteins is gaining traction due to their significance in understanding serotonin signaling pathways and their implications in treating psychiatric disorders. The study of HTR3D is particularly relevant in the context of the increasing incidence of mental health issues globally, as well as the need for targeted therapies that can mitigate side effects associated with traditional antidepressants. Previous studies have highlighted the potential of HTR3D in modulating neuromodulatory systems, thereby influencing neurotransmitter release and synaptic plasticity. In vitro expression systems have been utilized to produce recombinant HTR3D proteins, enabling detailed biochemical and pharmacological characterizations. These studies aim to elucidate the receptor's structural features, ligand-binding properties, and functional responses, which are essential for drug discovery. As researchers continue to explore the therapeutic targets within the serotonin receptor family, HTR3D stands out as a promising candidate for further investigation, particularly in the development of novel anxiolytics and antidepressants. Understanding the precise mechanisms of HTR3D could pave the way for innovative treatments, ultimately improving the quality of life for individuals suffering from serotonin-related disorders.
