Analytical Data
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基因名
CCL8
- Application
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别名
CCL8；MCP2；C-C motif chemokine 8
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P80075
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表达区间
24-99aa
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氨基酸序列
QPDSVSIPITCCFNVINRKIPIQRLESYTRITNIQCPKEAVIFKTKRGKE VCADPKERWVRDSMKHLDQIFQNLKP
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分子量
9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCL8, also known as Monocyte Chemoattractant Protein-2 (MCP-2), is a member of the CC chemokine family that plays a pivotal role in the immune response by attracting monocytes and other immune cells to sites of inflammation. This chemokine is primarily produced by macrophages and is implicated in various pathological conditions, including autoimmune diseases, cancer, and chronic inflammatory disorders. Studies have shown that CCL8 not only influences the recruitment of immune cells but also modulates their activities, contributing to both pro-inflammatory and anti-inflammatory responses. The interest in recombinant CCL8 protein has surged, driven by its potential as a therapeutic target and biomarker for disease progression. Researchers have aimed to produce and characterize recombinant CCL8 to investigate its biological functions and interactions with other immune modulators. Furthermore, understanding the signaling pathways activated by CCL8 can provide insights into its role in the immune system and its potential role in therapeutic interventions. Given its involvement in critical immune processes, recombinant CCL8 protein serves as a valuable tool for elucidating the molecular mechanisms underlying immune regulation and developing novel treatments for immune-related diseases. Overall, the study of CCL8 holds promise for advancing our understanding of immune responses and enhancing therapeutic strategies in various clinical settings.
