Analytical Data
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Gene name
PPP1R12C
- Application
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Alternative Names
LENG 3; LENG3; leukocyte receptor cluster (LRC) encoded novel gene 3; leukocyte receptor cluster (LRC) member 3; MBS 85; MBS85; Myosin binding subunit 85; p84; p85; PP12C_HUMAN; Ppp1r12c; protein phosphatase 1 regulatory (inhibitor) subunit 12C; protein phosphatase 1 myosin binding subunit of 85 kDa; protein phosphatase 1 myosin binding subunit p85; Protein phosphatase 1 myosin-binding subunit of 85 kDa; Protein phosphatase 1 myosin-binding subunit p85; Protein phosphatase 1 regulatory subunit 12C
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BZL4
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Expression Region
2-782 aa
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AA Sequence
SGEDGPAAG PGAAAAAARE RRREQLRQWG ARAGAEPGPG ERRARTVRFE RAAEFLAACA GGDLDEARLM LRAADPGPGA ELDPAAPPPA RAVLDSTNAD GISALHQACI DENLEVVRFL VEQGATVNQA DNEGWTPLHV AASCGYLDIA RYLLSHGANI AAVNSDGDLP LDLAESDAME GLLKAEIARR GVDVEAAKRA EEELLLHDTR CWLNGGAMPE ARHPRTGASA LHVAAAKGYI EVMRLLLQAG YDPELRDGDG WTPLHAAAHW GVEDACRLLA EHGGGMDSLT HAGQRPCDLA DEEVLSLLEE LARKQEDLRN QKEASQSRGQ EPQAPSSSKH RRSSVCRLSS REKISLQDLS KERRPGGAGG PPIQDEDEGE EGPTEPPPAE PRTLNGVSSP PHPSPKSPVQ LEEAPFSRRF GLLKTGSSGA LGPPERRTAE GAPGAGLQRS ASSSWLEGTS TQAKELRLAR ITPTPSPKLP EPSVLSEVTK PPPCLENSSP PSRIPEPESP AKPNVPTAST APPADSRDRR RSYQMPVRDE ESESQRKARS RLMRQSRRST QGVTLTDLKE AEKAAGKAPE SEKPAQSLDP SRRPRVPGVE NSDSPAQRAE APDGQGPGPQ AAREHRKVGK EWRGPAEGEE AEPADRSQES STLEGGPSAR RQRWQRDLNP EPEPESEEPD GGFRTLYAEL RRENERLREA LTETTLRLAQ LKVELERATQ RQERFAERPA LLELERFERR ALERKAAELE EELKALSDLR ADNQRLKDEN AALIRVISKL SK
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Molecular Weight
84.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PPP1R12C (Protein Phosphatase 1 Regulatory Subunit 12C) is an important regulatory protein that plays a key role in cellular processes by modulating the activity of Protein Phosphatase 1 (PP1), a serine/threonine phosphatase involved in a variety of biological functions, including cell division, muscle contraction, and signal transduction. Research into PPP1R12C has gained traction due to its potential implications in various diseases, including cancer, where dysregulation of PP1 activity can lead to uncontrolled cell proliferation and tumorigenesis. The protein is known to interact with several cellular pathways and can influence the phosphorylation status of numerous substrates, thus affecting overall cellular homeostasis. As a result, the generation and study of recombinant PPP1R12C protein have become critical for understanding its structure-function relationship, mechanisms of action, and regulatory roles within the cell. By producing and purifying this recombinant protein, researchers aim to dissect its interactions with PP1 and other signaling pathways, potentially uncovering novel therapeutic targets for diseases associated with PPP1R12C dysregulation. Moreover, elucidating the functional dynamics and regulatory mechanisms of PPP1R12C will contribute to a broader comprehension of cellular signaling networks, which may lead to advancements in treatment strategies for cancers and other pathological conditions linked to phosphatase activity. This background highlights the significance of PPP1R12C in cellular signaling and its potential implications in health and disease, underscoring the importance of continued research in this area.
