Analytical Data
-
基因名
SLC5A2
- Application
-
别名
SLC5A2；SGLT2；Sodium/glucose cotransporter 2
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P31639
-
表达区间
1-672aa
-
氨基酸序列
MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLLTLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQAPAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLMMAVAVFLWGFYA
-
分子量
73.9 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC5A2, also known as the sodium-glucose cotransporter 2 (SGLT2), plays a crucial role in the reabsorption of glucose in the proximal renal tubules. Its importance has surged in recent years due to its association with diabetes mellitus and related metabolic disorders. SLC5A2 is responsible for the uptake of glucose from the renal filtrate back into the bloodstream, thus maintaining glucose homeostasis. The overactivity of SLC5A2 contributes to hyperglycemia, prompting the search for selective inhibitors as therapeutic options. Research involving the recombinant expression of SLC5A2 facilitates a deeper understanding of its structure, function, and interaction with various ligands. By producing recombinant SLC5A2 proteins in heterologous systems, scientists can elucidate the molecular mechanisms of glucose transport, assess the impact of genetic variations, and screen potential drug candidates. Moreover, studying the biophysical properties and regulation of SLC5A2 at the protein level allows for the identification of novel pharmacological targets to develop effective treatments for diabetes. Given the rising prevalence of diabetes worldwide, understanding SLC5A2 and its potential as a therapeutic target is increasingly relevant in the field of metabolic disease research.
