Analytical Data
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Gene name
ICAM1
- Application
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Alternative Names
ICAM1；Intercellular adhesion molecule 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P05362
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Expression Region
28-480aa
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AA Sequence
QTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKKELLLPGNNRK VYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPV GKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRR DHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVL EVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVS VTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSEGTE VTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEV AGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLP ELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSP RYE
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Molecular Weight
50 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ICAM-1 (Intercellular Adhesion Molecule 1) is a crucial glycoprotein involved in the immune response, predominantly expressed on endothelial cells and some leukocytes. It plays a significant role in mediating cell-cell adhesion and facilitating the migration of immune cells to sites of inflammation. Given its involvement in various pathological conditions, including autoimmune diseases, cancer, and infectious diseases, the study of ICAM-1 has garnered considerable attention. The recombinant protein version of ICAM-1 is particularly valuable for research purposes, as it allows for the investigation of its structural and functional properties in vitro. Through the expression and purification of ICAM-1 recombinant proteins, researchers can explore its interactions with ligands, such as LFA-1 (Lymphocyte Function-associated Antigen-1), and assess its role in cell signaling pathways. Furthermore, ICAM-1's potential as a therapeutic target in modulating immune responses makes it an attractive avenue for drug development. Consequently, advancing our understanding of ICAM-1 through recombinant protein studies can illuminate the underlying mechanisms of various diseases and pave the way for innovative therapeutic strategies.
