Analytical Data
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基因名
HTR7
- Application
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别名
HTR7；5-hydroxytryptamine receptor 7
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P34969
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表达区间
1-479aa
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氨基酸序列
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLS EVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNC LVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIF GHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMA KMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYI PMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTAR PFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQ CQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVS VWVLQSPDHHNWLADKMLTTVEKKVMIHD
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分子量
56 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HTR7, or 5-hydroxytryptamine receptor 7, is a member of the serotonin receptor family that plays a vital role in various physiological processes, including mood regulation, anxiety, and circadian rhythm. Its significance in neuropsychiatric disorders has garnered considerable research interest, especially as it is implicated in conditions like depression, schizophrenia, and anxiety disorders. The study of HTR7 recombinant proteins has emerged as a crucial aspect in understanding the receptor's function and its interactions with endogenous ligands and other cellular partners. By generating HTR7 recombinant proteins, researchers can investigate the receptor's structure-function relationship, ligand binding characteristics, and downstream signaling pathways. This enables the exploration of HTR7 as a potential therapeutic target. Advances in recombinant DNA technology and protein expression systems have facilitated the production of high-quality HTR7 proteins, which are essential for biophysical and biochemical studies. These studies are expected to offer insights into the molecular mechanisms underlying HTR7 activation and its role in signaling pathways relevant to mood regulation and stress response, ultimately contributing to the development of novel pharmacological interventions for treating neuropsychiatric disorders associated with dysregulated serotonin signaling.
