Analytical Data
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Gene name
HTR2B
- Application
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Alternative Names
HTR2B；5-hydroxytryptamine receptor 2B
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P41595
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Expression Region
1-481aa
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AA Sequence
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQ GNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVAD LLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAIS VDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVD NPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYL VKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLC DSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYR ATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRS STIQSSSIILLDTLLLTENEGDKTEEQVSYV
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Molecular Weight
70 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The HTR2B gene encodes the 5-Hydroxytryptamine receptor 2B (5-HT2B), a member of the serotonin receptor family, which plays a crucial role in various physiological processes, including mood regulation, appetite control, and cardiovascular function. Dysregulation of HTR2B has been implicated in several psychiatric disorders, such as schizophrenia and depression, as well as cardiovascular diseases. Research into HTR2B recombinant proteins allows for a deeper understanding of the receptor's structure, function, and signaling pathways. It facilitates the exploration of potential therapeutic targets, as the 5-HT2B receptor is a candidate for developing novel pharmacological interventions. Recent advancements in recombinant protein technology have enabled the production of functional HTR2B proteins, which can be used in assays to characterize ligand-receptor interactions and assess the effects of various compounds. This research is critical not only for understanding the pharmacodynamics and pharmacokinetics of existing drugs but also for discovering new therapeutic agents that could ameliorate conditions associated with HTR2B dysregulation. Overall, the study of HTR2B recombinant proteins is pivotal in unraveling the complexities of serotonin signaling and its implications for health and disease management.
