Analytical Data
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基因名
BTN3A3
- Application
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别名
BTN3A3；BTF3；Butyrophilin subfamily 3 member A3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00478
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表达区间
30-248aa
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氨基酸序列
Q FSVLGPSGPI LAMVGEDADL PCHLFPTMSA ETMELRWVSS SLRQVVNVYA DGKEVEDRQS APYRGRTSIL RDGITAGKAA LRIHNVTASD SGKYLCYFQD GDFYEKALVE LKVAALGSDL HIEVKGYEDG GIHLECRSTG WYPQPQIKWS DTKGENIPAV EAPVVADGVG LYAVAASVIM RGSSGGGVSC IIRNSLLGLE KTASISIADP FFRSAQPW
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分子量
26 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BTN3A3, or B7 homolog 3, is a member of the B7 family of immune-regulatory proteins, primarily expressed on immune cells such as T cells and antigen-presenting cells. Research into BTN3A3 has gained momentum due to its critical role in modulating the immune response, particularly in cancer and infectious diseases. It has been shown to influence T cell activation and proliferation, leading to both co-stimulatory and inhibitory signals that impact tumor immunity. BTN3A3 interacts with various receptors and ligands, suggesting a complex regulatory network that governs immune responses. Additionally, its expression levels and functional implications in different disease contexts make it a compelling target for immunotherapeutic strategies. Understanding the molecular mechanisms behind BTN3A3's action can open new avenues for enhancing anti-tumor immunity and improving vaccine efficacy. As a recombinant protein, BTN3A3 offers the potential for detailed studies on its structure-function relationships, interactions with immune cell receptors, and subsequent effects on immune modulation, thus contributing to the broader understanding of immune regulation in health and disease.
