Analytical Data
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Gene name
CSE1L
- Application
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Alternative Names
CSE1L；CAS；XPO2；Exportin-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P55060
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Expression Region
1-200aa
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AA Sequence
MELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPLLLLTLLEKSQDNVIKVCASVTFKNYIKRNWRIVEDEPNKICEADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGREDFPQKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAFALPLTNLFKATIELCSTHAN
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Molecular Weight
39.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CSE1L (Chromosome Segregation 1-Like) is a protein that plays a critical role in cellular processes such as cell division and protein transport. Recent studies have indicated that CSE1L is involved in maintaining genomic stability, with dysregulation of its expression linked to various diseases, including cancer. Researchers have focused on CSE1L due to its essential functions in the nuclear transport of proteins and its role in the cell cycle, particularly during mitosis. The protein is known to interact with several key proteins, influencing their localization and activity within the cell. Given its potential implications in tumorigenesis and other pathologies, understanding the structure and function of CSE1L has become increasingly important. Investigating the mechanisms that regulate CSE1L activity, as well as its interactions with other cellular components, could provide insights into therapeutic approaches for cancer treatment and other diseases associated with cell cycle dysregulation. The ongoing research on CSE1L not only advances our understanding of fundamental biological processes but also opens new avenues for targeted therapies that can manipulate its function to restore normal cellular behavior.
