Analytical Data
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基因名
IL12RB2
- Application
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别名
IL12RB2；Interleukin-12 receptor subunit beta-2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99665
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表达区间
24-622aa
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氨基酸序列
KIDACKRGDVTVKPSHVILLGSTVNITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWDIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLPTRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIRVYALSGDQGGCSSILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSLQPRVTYVLWMTALTAAGESSHGNEREFCLQGKAN
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分子量
69.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IL12RB2 (Interleukin 12 Receptor Subunit Beta 2) is a critical component of the interleukin-12 receptor complex, which plays a pivotal role in the immune response, particularly in the activation of T cells and natural killer (NK) cells. Research into IL12RB2 has gained momentum due to its significance in various immunological disorders and its potential as a therapeutic target in cancer and autoimmune diseases. The binding of interleukin-12 to its receptor activates intracellular signaling pathways that enhance the production of pro-inflammatory cytokines, thereby promoting the differentiation and proliferation of immune cells. However, aberrations in IL12RB2 signaling may contribute to immune dysregulation, making it a target of interest for both basic and translational research. Recombinant IL12RB2 protein has been produced to aid in these studies, allowing for a clearer understanding of receptor function, the effects of its ligands, and how it influences immune system dynamics. This research could pave the way for novel therapeutic strategies aimed at modulating immune responses in various diseases, highlighting the importance of IL12RB2 in therapeutic advancements and our overall understanding of immune regulation.
