Analytical Data
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基因名
PTH1R
- Application
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别名
PTH1R；PTHR；Parathyroid hormone/parathyroid hormone-related peptide receptor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q03431
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表达区间
27-188aa
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氨基酸序列
DADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPASIMESDKGWTSASTSG KPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEV VAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTN ETREREVFDRLG
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分子量
20 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTH1R (Parathyroid Hormone 1 Receptor) is a critical G protein-coupled receptor that plays a significant role in regulating calcium and phosphate metabolism through its interaction with parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP). Dysregulation of PTH1R signaling is implicated in various bone and mineral disorders, including osteoporosis, hypoparathyroidism, and certain types of cancers. Due to the receptor's vital functions, understanding its structure and signaling mechanisms is essential for developing targeted therapies. Recombinant PTH1R proteins, generated through advanced biotechnological methods, facilitate the exploration of the receptor's properties, enabling researchers to investigate its ligand-binding characteristics and downstream signaling pathways. These studies can lead to insights into the pharmacological modulation of PTH1R, paving the way for novel treatments for calcium-related disorders. Moreover, the generation of PTH1R recombinant proteins serves as a platform for high-throughput screening of small molecules, which may identify new drug candidates that specifically target this receptor. Overall, the investigation of PTH1R recombinant proteins is crucial for advancing our understanding of mineral homeostasis and developing innovative therapeutic strategies for related diseases.
