Analytical Data
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基因名
SRRM2
- Application
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别名
SRRM2；KIAA0324；SRL300；SRM300；Serine/arginine repetitive matrix Protein 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UQ35
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表达区间
1666-2089aa
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氨基酸序列
RTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSR
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分子量
53.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SRRM2 (serine/arginine-rich splicing factor 2) is a critical protein involved in the regulation of pre-mRNA splicing, a vital process for gene expression and cellular function. As a member of the serine-arginine-rich (SR) protein family, SRRM2 plays a key role in the assembly of spliceosomal complexes, influencing alternative splicing decisions that define protein diversity in eukaryotic organisms. Research has shown that SRRM2 is not only essential for neuronal development but also implicated in various diseases, including cancer and neurodegenerative disorders. Its dysregulation can lead to aberrant splicing events, which may contribute to tumorigenesis or neurodegeneration. Understanding the structural and functional properties of SRRM2 is crucial for elucidating its role in splicing regulation and its potential as a therapeutic target. Recombinant SRRM2 protein is increasingly being utilized in research to explore its interactions with RNA and other splicing factors, thereby providing insights into the molecular mechanisms underlying splicing and associated pathologies. This research is paving the way for novel approaches to manipulate splicing processes in therapeutic contexts, making SRRM2 a protein of significant interest in both basic and applied molecular biology.
