Analytical Data
-
基因名
PMS2CL
- Application
-
别名
PMS2CL; PMS2P13; Protein PMS2CL; PMS2-C terminal-like protein
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q68D20
-
表达区间
1-193 aa
-
氨基酸序列
MHAADLEKPM VEKQDQSPSL RTGEEKRDVS ISRLREAFSL RHTTENKPHS PKTPEPRRSP LGQKRGMSSS STSDAISDRG VLRPQKEAVS SSQGPSDPTD RAEVEKDSGH GSTSVDSEGF SIPDTGSHCS SECVASTPGD RGSQEHVDSQ EKAPETDDSF SDVDCHSNQE DTGCKFQVLP QPTNLTSPNT KVF
-
分子量
20.9 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PMS2CL, a protein involved in the mismatch repair (MMR) system, plays a critical role in maintaining genomic stability by correcting DNA replication errors. Deficiencies in MMR, including those involving PMS2, are associated with increased mutation rates and are linked to various cancers, particularly Lynch syndrome, a hereditary condition leading to colorectal and other cancers. The study of PMS2CL recombinant proteins aims to elucidate the structural and functional mechanisms underlying its role in MMR. By producing and characterizing these recombinant proteins, researchers can explore their interactions with other MMR components, investigate their enzymatic activities, and identify potential post-translational modifications that may affect their function. Understanding the biology of PMS2CL can provide insights into its contributions to cancer development and highlight potential therapeutic targets. Moreover, the recombinant forms of PMS2CL can be utilized in high-throughput screening assays to discover small molecules that may enhance its function or restore activity in defective MMR systems. This research not only advances our comprehension of fundamental DNA repair processes but also fosters the development of novel strategies for cancer prevention and treatment.
