Analytical Data
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基因名
BRUNOL4
- Application
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别名
CELF4; BRUNOL4; CUGBP Elav-like family member 4; CELF-4; Bruno-like Protein 4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BZC1
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表达区间
1-486aa
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氨基酸序列
MYIKMATLAN GQADNASLST NGLGSSPGSA GHMNGLSHSP GNPSTIPMKD HDAIKLFIGQ IPRNLDEKDL KPLFEEFGKI YELTVLKDRF TGMHKGCAFL TYCERESALK AQSALHEQKT LPGMNRPIQV KPADSESRGG SSCLRQPPSQ DRKLFVGMLN KQQSEDDVRR LFEAFGNIEE CTILRGPDGN SKGCAFVKYS SHAEAQAAIN ALHGSQTMPG ASSSLVVKFA DTDKERTMRR MQQMAGQMGM FNPMAIPFGA YGAYAQALMQ QQAALMASVA QGGYLNPMAA FAAAQMQQMA ALNMNGLAAA PMTPTSGGST PPGITAPAVP SIPSPIGVNG FTGLPPQANG QPAAEAVFAN GIHPYPAQSP TAADPLQQAY AGVQQYAGPA AYPAAYGQIS QAFPQPPPMI PQQQREGPEG CNLFIYHLPQ EFGDAELMQM FLPFGFVSFD NPASAQTAIQ AMNGFQIGMK RLKVQLKRPK DANRPY
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分子量
51.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BRUNOL4 is a member of the BRUNO family of RNA-binding proteins and plays a crucial role in post-transcriptional regulation of gene expression. This protein is particularly significant in processes such as mRNA stability, translation, and localization, which are essential for various cellular functions and developmental processes. The study of BRUNOL4 has gained attention due to its potential involvement in neurodevelopmental disorders and cancers, as it is implicated in the regulation of genes associated with these conditions. Recent research has shown that BRUNOL4 interacts with specific RNA elements, influencing the fate of target mRNAs and thus modulating protein synthesis. Understanding the molecular mechanisms behind BRUNOL4's function can provide insights into how dysregulation of this protein contributes to disease, offering potential avenues for therapeutic intervention. Moreover, studying BRUNOL4 helps elucidate the broader biological roles of RNA-binding proteins in cellular homeostasis and their contributions to pathological states, marking it as a promising target for further investigation in both basic and applied biomedical research.
