Analytical Data
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基因名
MINPP1
- Application
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别名
MINPP1；MIPP；Multiple inositol polyphosphate phosphatase 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UNW1
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表达区间
31-487aa
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氨基酸序列
SLLEPRDPVASSLSPYFGTKTRYEDVNPVLLSGPEAPWRDPELLEGTCTP VQLVALIRHGTRYPTVKQIRKLRQLHGLLQARGSRDGGASSTGSRDLGAA LADWPLWYADWMDGQLVEKGRQDMRQLALRLASLFPALFSRENYGRLRLI TSSKHRCMDSSAAFLQGLWQHYHPGLPPPDVADMEFGPPTVNDKLMRFFD HCEKFLTEVEKNATALYHVEAFKTGPEMQNILKKVAATLQVPVNDLNADL IQVAFFTCSFDLAIKGVKSPWCDVFDIDDAKVLEYLNDLKQYWKRGYGYT INSRSSCTLFQDIFQHLDKAVEQKQRSQPISSPVILQFGHAETLLPLLSL MGYFKDKEPLTAYNYKKQMHRKFRSGLIVPYASNLIFVLYHCENAKTPKE QFRVQMLLNEKVLPLAYSQETVSFYEDLKNHYKDILQSCQTSEECELARA NSTSDEL
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分子量
54 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MINPP1, or Mannose-6-Phosphate Isomerase, is a crucial enzyme involved in the regulation of mannose-6-phosphate, a significant precursor for glycoprotein synthesis and lysosomal enzyme targeting. It plays a vital role in maintaining cellular homeostasis and has been implicated in various pathological conditions, including cancer and neurodegenerative diseases. Research into MINPP1 recombinant protein has gained considerable attention due to its potential therapeutic applications. The ability to produce MINPP1 in a recombinant form allows for detailed studies of its structure and function, providing insights into its enzymatic activity and potential as a biomarker or drug target. Additionally, understanding the regulatory mechanisms that govern MINPP1 expression and activity can offer valuable information for developing strategies to manipulate its function in disease contexts. Recent advances in molecular biology techniques, such as CRISPR and advanced purification methods, have facilitated the production and characterization of MINPP1, paving the way for exploring its role in cellular processes and its potential in biomedicine. As research progresses, the elucidation of MINPP1's mechanisms may lead to novel interventions for diseases associated with glycosylation imbalances and other metabolic disorders.
