Analytical Data
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Gene name
TRIP12
- Application
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Alternative Names
TRIP12；KIAA0045；ULF；E3 ubiquitin-Protein ligase TRIP12
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14669
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Expression Region
1881-1992aa
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AA Sequence
ECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGQQSFHLS
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Molecular Weight
19.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TRIP12, also known as thyroid hormone receptor-interacting protein 12, is an E3 ubiquitin ligase that plays a crucial role in various cellular processes, including protein degradation, cell cycle regulation, and DNA damage response. Its dysregulation has been implicated in a range of diseases, including cancer and neurodegenerative disorders. Recent studies have highlighted its potential involvement in the regulation of gene expression by modulating the turnover of transcription factors and other signaling molecules. Understanding the molecular mechanisms by which TRIP12 exerts its effects is essential for exploring its potential as a therapeutic target. Researchers are investigating TRIP12's interactions with various substrates and its role in different cellular contexts to better comprehend its function in health and disease. The growing interest in TRIP12 underscores the need for more comprehensive studies to elucidate its biological significance and therapeutic promise in combating relevant diseases.
