Analytical Data
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基因名
PLXNA2
- Application
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别名
Plexin-A2; PlexinA2 ; PLXA2; PLXA2_HUMAN; PLXNA2; Semaphorin receptor OCT
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75051
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表达区间
1-164 aa
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氨基酸序列
MHSQVFSAFPYSLPLRFWVNVIKNPQFVFDIHKGSITDACLSVVAQTFMDSCSTSEHRLDKDSPSNKLLYAKDIPSYKSWVERYYADIAKLPAISDQDMNAYLAEQSRLHAVEFNMLSALNEIYSYVSKYSEELIGALEQDEQARRQRLAYKVEQLINAMSIES
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分子量
43.78 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PLXNA2 (Plexin A2) is a significant member of the Plexin family of receptors, which play a crucial role in the regulation of various biological processes, including neuronal guidance, immune response, and cancer progression. Research has shown that PLXNA2 functions as a receptor for semaphorins, a class of secreted proteins involved in directing the development of the nervous system. Abnormal expression or mutations in PLXNA2 have been associated with various neurological disorders and certain cancers, highlighting its potential as a therapeutic target. The recombinant PLXNA2 protein is extensively studied to elucidate its structural characteristics, signaling pathways, and biological functions. By producing this protein in a laboratory setting, researchers aim to investigate its interactions with semaphorins and other binding partners, providing insights into molecular mechanisms that underlie its physiological roles. Furthermore, PLXNA2's involvement in axon guidance and its implications in tumor biology have made it a focal point for novel therapeutic strategies, including targeted drug development. Understanding the functional dynamics of PLXNA2 through recombinant protein studies can pave the way for innovative treatments in neurodegenerative diseases and cancer, making this research critically important in the fields of molecular biology and translational medicine.












