Analytical Data
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Gene name
BRI3BP
- Application
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Alternative Names
BRI3BP; KG19; BRI3-binding Protein; I3-binding Protein; Cervical cancer 1 proto-oncogene-binding Protein KG19; HCCRBP-1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8WY22
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Expression Region
1-251aa
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AA Sequence
MGARASGGPLARAGLLLLLLLLLLLGLLAPGAQGARGRGGAEKNSYRRTVNTFSQSVSSLFGEDNVRAAQKFLARLTERFVLGVDMFVETLWKVWTELLDVLGLDVSNLSQYFSPASVSSSPARALLLVGVVLLAYWFLSLTLGFTFSVLHVVFGRFFWIVRVVLFSMSCVYILHKYEGEPENAVLPLCFVVAVYFMTGPMGFYWRSSPSGPSNPSNPSVEEKLEHLEKQVRLLNIRLNRVLESLDRSKDK
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Molecular Weight
54.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BRI3BP, or BRI3 binding protein, has garnered attention in the field of molecular biology due to its potential roles in cellular processes and disease mechanisms. Discovered as a binding partner of BRI3, a protein implicated in regulating cell growth and differentiation, BRI3BP has been linked to various biological functions, including apoptosis, inflammation, and cellular stress responses. Research suggests that BRI3BP may play a crucial role in neurodegenerative diseases, cancer, and metabolic disorders, potentially serving as a biomarker or therapeutic target. The exploration of BRI3BP's structure and function has been enhanced by the development of recombinant proteins, enabling more precise studies into its interactions and mechanisms of action. Scientists are particularly interested in understanding how BRI3BP modulates signaling pathways, as this could provide insights into its involvement in pathophysiological conditions. Overall, the study of BRI3BP and its recombinant variants presents an exciting avenue for understanding complex cellular dynamics and developing novel strategies for disease intervention.
