Analytical Data
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Gene name
TREML2
- Application
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Alternative Names
TREML2；C6orf76；Trem-like transcript 2 Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5T2D2
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Expression Region
19-268aa
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AA Sequence
GPSADSVYTKVRLLEGETLSVQCSYKGYKNRVEGKVWCKIRKKKCEPGFA RVWVKGPRYLLQDDAQAKVVNITMVALKLQDSGRYWCMRNTSGILYPLMG FQLDVSPAPQSERNIPFTHLDNILKSGTVTTGQAPTSGPDAPFTTGVMVF TPGLITLPRLLASTRPASKTGYSFTATSTTSQGPRRTMGSQTVTASPSNA RDSSAGPESISTKSGDLSTRSPTTGLCLTSRSLLNRLPSMPSIRHQDVYS VDDIEGRMDEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRT PEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVL TVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRE EMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
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Molecular Weight
54 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TREML2 (TREM-like transcript 2) is a member of the TREM family of proteins, which are implicated in immune regulation and cell signaling. Originally identified in humans, TREML2 exhibits a unique expression pattern in immune cells, suggesting its potential role in modulating immune responses, particularly in contexts such as inflammation and autoimmune diseases. Research has shown that TREML2 can influence the activation and differentiation of immune cells, thereby potentially affecting disease outcomes. Its structural characteristics, including the presence of an immunoglobulin-like domain, indicate its involvement in receptor-ligand interactions. The study of TREML2 recombinant proteins has gained attention as a tool to unravel the functional mechanisms of TREML2 in immune modulation. By producing TREML2 as a recombinant protein, researchers can investigate its binding affinities, signaling pathways, and interactions with various ligands and receptors. This knowledge can enhance our understanding of its role in pathophysiological settings, paving the way for therapeutic applications in diseases where TREML2 is dysregulated. Moreover, the exploration of TREML2 in different biological contexts may provide insights into novel immune therapeutic strategies and biomarker developments, contributing significantly to the advancement of immunology and precision medicine. Through the systematic study of TREML2 recombinant proteins, researchers aim to elucidate the complexities of immune regulation and develop interventions targeting this intriguing protein for better health outcomes.
