Analytical Data
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基因名
BOK
- Application
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别名
Bok; MtdBcl-2-related ovarian killer Protein; Apoptosis activator Mtd; Protein matador
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O35425
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表达区间
1-213aa
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氨基酸序列
MEVLRRSSVF AAEIMDAFDR SPTDKELVAQ AKALGREYVH ARLLRAGLSW SAPERASPAP GGRLAEVCTV LLRLGDELEQ IRPSVYRNVA RQLHIPLQSE PVVTDAFLAV AGHIFSAGIT WGKVVSLYSV AAGLAVDCVR QAQPAMVHAL VDCLGEFVRK TLATWLRRRG GWTDVLKCVV STDPGFRSHW LVATLCSFGR FLKAAFFLLL PER
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分子量
23.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Bok, or Bcl-2-related ovarian killer protein, is a member of the Bcl-2 family, known for its role in apoptosis regulation. The study of Bok's recombinant protein has garnered attention due to its potential implications in cancer research and therapy. Given that Bok's expression is often downregulated in various cancer types, understanding its functional mechanisms could provide insights into tumorigenesis and the development of targeted therapies. Researchers are particularly interested in elucidating how Bok interacts with other Bcl-2 family members and contributes to the apoptotic pathway, providing a crucial balance between cell survival and death. Recombinant Bok protein enables the exploration of its biochemical properties, interaction dynamics, and inhibitory effects on oncogenic pathways in vitro and in vivo. Furthermore, as apoptosis is a key process in cancer progression, the ability to manipulate Bok's activity could pave the way for novel therapeutic strategies aimed at restoring apoptotic mechanisms in cancer cells. Thus, the ongoing investigation into the recombinant Bok protein promises significant contributions to the understanding of cell death regulation and the development of innovative cancer treatment modalities.
