Analytical Data
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Gene name
BOK
- Application
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Alternative Names
Bok; MtdBcl-2-related ovarian killer Protein; Apoptosis activator Mtd; Protein matador
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O35425
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Expression Region
1-213aa
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AA Sequence
MEVLRRSSVF AAEIMDAFDR SPTDKELVAQ AKALGREYVH ARLLRAGLSW SAPERASPAP GGRLAEVCTV LLRLGDELEQ IRPSVYRNVA RQLHIPLQSE PVVTDAFLAV AGHIFSAGIT WGKVVSLYSV AAGLAVDCVR QAQPAMVHAL VDCLGEFVRK TLATWLRRRG GWTDVLKCVV STDPGFRSHW LVATLCSFGR FLKAAFFLLL PER
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Molecular Weight
23.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Bok, or Bcl-2-related ovarian killer protein, is a member of the Bcl-2 family, known for its role in apoptosis regulation. The study of Bok's recombinant protein has garnered attention due to its potential implications in cancer research and therapy. Given that Bok's expression is often downregulated in various cancer types, understanding its functional mechanisms could provide insights into tumorigenesis and the development of targeted therapies. Researchers are particularly interested in elucidating how Bok interacts with other Bcl-2 family members and contributes to the apoptotic pathway, providing a crucial balance between cell survival and death. Recombinant Bok protein enables the exploration of its biochemical properties, interaction dynamics, and inhibitory effects on oncogenic pathways in vitro and in vivo. Furthermore, as apoptosis is a key process in cancer progression, the ability to manipulate Bok's activity could pave the way for novel therapeutic strategies aimed at restoring apoptotic mechanisms in cancer cells. Thus, the ongoing investigation into the recombinant Bok protein promises significant contributions to the understanding of cell death regulation and the development of innovative cancer treatment modalities.
