Analytical Data
-
基因名
BCS1L
- Application
-
别名
BCS1L; BCS1; Mitochondrial chaperone BCS1; h-BCS1; BCS1-like Protein
-
种属
Human
-
表达系统
E. coli
-
标签
GST-tag at N-terminal
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q9Y276
-
表达区间
1-419aa
-
氨基酸序列
MPLSDFILALKDNPYFGAGFGLVGVGTALALARKGVQLGLVAFRRHYMITLEVPARDRSYAWLLSWLTRHSTRTQHLSVETSYLQHESGRISTKFEFVPSPGNHFIWYRGKWIRVERSREMQMIDLQTGTPWESVTFTALGTDRKVFFNILEEARELALQQEEGKTVMYTAVGSEWRPFGYPRRRRPLNSVVLQQGLADRIVRDVQEFIDNPKWYTDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLLSLTDSSLSDDRLNHLLSVAPQQSLVLLEDVDAAFLSRDLAVENPVKYQGLGRLTFSGLLNALDGVASTEARIVFMTTNHVDRLDPALIRPGRVDLKEYVGYCSHWQLTQMFQRFYPGQAPSLAENFAEHVLRATNQISPAQVQGYFMLYKNDPVGAIHNAESLRR
-
分子量
73.9 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Recombinant Human JCHAIN Protein，His
Cat：PA2000-1703
Recombinant Human BCORL2 Protein，GST
Cat：PA2000-5785
Protein Description
BCS1L (BCS1-like) is a crucial mitochondrial protein that plays a significant role in the assembly of the mitochondrial respiratory complex V, also known as ATP synthase. Mutations in the BCS1L gene are associated with a range of mitochondrial diseases, particularly affecting energy metabolism and leading to symptoms such as encephalopathy, exercise intolerance, and developmental delays. The importance of BCS1L lies in its function in facilitating the insertion of specific subunits into the ATP synthase complex, thereby playing a key role in maintaining mitochondrial function and cellular energy production. Research into BCS1L has gained momentum as scientists aim to uncover the molecular mechanisms underlying its function, the consequences of genetic mutations, and potential therapeutic strategies for mitochondrial disorders. Functional studies of recombinant BCS1L proteins have provided insights into the protein’s structure, interaction with other mitochondrial components, and the impact of pathogenic variants. Understanding BCS1L's role in mitochondrial biogenesis and function is not only vital for elucidating the pathophysiology of related diseases but also holds promise for developing targeted therapies that could potentially alleviate symptoms or improve mitochondrial function in affected individuals. Overall, the study of BCS1L recombinant proteins is essential for advancing our knowledge of mitochondrial biology and for addressing the challenges associated with mitochondrial diseases.
