Analytical Data
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基因名
PIGO
- Application
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别名
PIGO; UNQ632/PRO1249; GPI ethanolamine phosphate transferase 3; EC 2.-.-.-; Phosphatidylinositol-glycan biosynthesis class O protein; PIG-O
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TEQ8
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表达区间
1-454 aa
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氨基酸序列
MDSGEWEVSNQHVLGVDHCGHKHGPHHPEMAKKLSQMDQVIQGLVERLENDTLLVVAGDHGMTTNGDHGGDSELEVSAALFLYSPTAVFPSTPPEEPEVIPQVSLVPTLALLLGLPIPFGNIGEVMAELFSGGEDSQPHSSALAQASALHLNAQQVSRFLHTYSAATQDLQAKELHQLQNLFSKASADYQWLLQSPKGAEATLPTVIAELQQFLRGARAMCIESWARFSLSFLLLHLLAAGIPVTTPGPFTVPWQAVSAWALMATQTFYSTGHQPVFPAIHWHAAFVGFPEGHGSCTWLPALLVGANTFASHLLFAVGCPLLLLWPFLCESQGLRKRQQPPGNEADARVRPEEEEEPLMEMRLRDAPQHFYAALLQLGLKYLFILGIQILACALAASILRRHLMVWKVFAPKFIFEAVGFIVSSVGLLLGIALVMRVDGAVSSWFRQLFLAQQR
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分子量
75.68 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PIGO (Phosphatidylinositol Glycan Class O) is a crucial protein involved in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors, which are essential for the membrane attachment of various proteins in eukaryotic cells. Research into PIGO is motivated by its significant role in cell signaling, immune responses, and the pathology of several diseases, including cancer and neurodegenerative disorders. PIGO participates in anchoring proteins that modulate cellular processes, making it a target of interest in understanding both normal physiological functions and disease mechanisms. Dysregulation of PIGO and related pathways can lead to altered protein localization and function, contributing to abnormal cell behavior. Moreover, the study of PIGO and its interactions may pave the way for therapeutic interventions by enhancing our knowledge of GPI anchor biosynthesis and its implications in health and disease. Given the complexity of GPI-anchored proteins and their diverse functionalities, ongoing studies aim to elucidate the structural and functional characteristics of PIGO, providing insights into its regulatory mechanisms and potential roles in therapeutic applications.
