Analytical Data
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Gene name
AZI2
- Application
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Alternative Names
5 azacytidine induced Protein 2; 5-azacytidine-induced Protein 2; AA410145
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H6S1
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Expression Region
1-392aa
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AA Sequence
MDALVEDDIC ILNHEKAHKR DTVTPVSIYS GDESVASHFA LVTAYEDIKK RLKDSEKENS LLKKRIRFLE EKLIARFEEE TSSVGREQVN KAYHAYREVC IDRDNLKSKL DKMNKDNSES LKVLNEQLQS KEVELLQLRT EVETQQVMRN LNPPSSNWEV EKLSCDLKIH GLEQELELMR KECSDLKIEL QKAKQTDPYQ EDNLKSRDLQ KLSISSDNMQ HAYWELKREM SNLHLVTQVQ AELLRKLKTS TAIKKACAPV GCSEDLGRDS TKLHLMNFTA TYTRHPPLLP NGKALCHTTS SPLPGDVKVL SEKAILQSWT DNERSIPNDG TCFQEHSSYG RNSLEDNSWV FPSPPKSSET AFGETKTKTL PLPNLPPLHY LDQHNQNCLY KN
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Molecular Weight
71.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AZI2, or Apoptosis-Associated Speck-like Protein containing a CARD, is a critical protein involved in apoptotic signaling and inflammation modulation. This protein is part of the NOD-like receptor family, which plays a significant role in the innate immune response by detecting pathogens and cellular stress. Research into AZI2 has highlighted its capacity to form multimeric complexes that facilitate the activation of caspases, thereby promoting programmed cell death in response to various stimuli. Additionally, AZI2 has been implicated in the pathogenesis of several diseases, including cancer and autoimmune disorders, where dysregulation of apoptosis and inflammation occurs. Understanding the structural and functional aspects of AZI2 is essential for elucidating its role in cellular homeostasis and its potential as a therapeutic target. Recent studies have focused on the reconstitution of AZI2 as a recombinant protein to investigate its interactions with other cellular components and define its mechanistic pathways. This research is crucial not only for understanding the fundamental biology of AZI2 but also for paving the way for novel strategies in disease intervention, particularly in conditions characterized by aberrant apoptosis and excessive inflammation.
