Analytical Data
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基因名
PHIP
- Application
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别名
PHIP; DCAF14; WDR11; PH-interacting protein; PHIP; DDB1- and CUL4-associated factor 14; IRS-1 PH domain-binding protein; WD repeat-containing protein 11
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WWQ0
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表达区间
1599-1705 aa
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氨基酸序列
TLSKSSAVIEQGDCKNNALVPGTIQVNGHGGQPSKLVKRGPGRKPKVEVNTNSGEIIHKKRGRKPKKLQYAKPEDLEQNNVHPIRDEVLPSSTCNFLSETNNVKEDL
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分子量
37.51 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PHIP (PH domain and leucine-rich repeat protein) is an essential protein implicated in various cellular processes, including signal transduction, cellular growth, and differentiation. Research has increasingly focused on PHIP due to its association with critical physiological and pathological conditions, such as cancer and metabolic disorders. The protein is known to interact with multiple signaling pathways, particularly those related to insulin signaling and glucose metabolism, making it a potential target for therapeutic intervention. Advances in recombinant DNA technology have enabled the production of PHIP in a controlled laboratory setting. This recombinant PHIP allows for detailed structural and functional studies, helping to unravel its biological roles and mechanisms of action. By understanding how PHIP participates in cellular signaling cascades, researchers aim to elucidate its contributions to disease processes. Moreover, dissecting the structure-function relationship of PHIP can lead to the identification of novel biomarkers or drug targets, ultimately contributing to the development of innovative strategies for disease management. As such, the study of recombinant PHIP represents a significant avenue in biomedical research, linking basic science to potential clinical applications.
