Analytical Data
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Gene name
XRCC3
- Application
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Alternative Names
XRCC3；DNA repair Protein XRCC3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43542
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Expression Region
1-346aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMDLDLLDLNPRIIAAIKKAKLKSVKEVLHF SGPDLKRLTNLSSPEVWHLLRTASLHLRGSSILTALQLHQQKERFPTQHQ RLSLGCPVLDALLRGGLPLDGITELAGRSSAGKTQLALQLCLAVQFPRQH GGLEAGAVYICTEDAFPHKRLQQLMAQQPRLRTDVPGELLQKLRFGSQIF IEHVADVDTLLECVNKKVPVLLSRGMARLVVIDSVAAPFRCEFDSQASAP RARHLQSLGATLRELSSAFQSPVLCINQVTEAMEEQGAAHGPLGFWDERV SPALGITWANQLLVRLLADRLREEEAALGCPARTLRVLSAPHLPPSSCSY TISAEGVRGTPGTQSH
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Molecular Weight
40 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
XRCC3, a member of the X-ray repair cross-complementing (XRCC) family, plays a crucial role in the repair of DNA double-strand breaks through homologous recombination, a vital mechanism for maintaining genomic stability. Its importance is underscored by its involvement in the repair processes initiated by ionizing radiation and various genotoxic agents, which can lead to cellular damage and increased mutation rates. Mutations or deficiencies in the XRCC3 gene have been implicated in a range of pathological conditions, including cancer susceptibility and sensitivity to chemotherapeutic agents. Given the pivotal role of XRCC3 in DNA repair, researchers have focused on characterizing its protein structure, functional domains, and interactions with other proteins involved in the repair pathway. Recombinant XRCC3 protein studies have enabled the investigation of its biochemical properties, regulatory mechanisms, and potential as a therapeutic target. By understanding the specific roles and actions of XRCC3, insights into cancer treatments and personalized medicine approaches may emerge, highlighting the significance of ongoing XRCC3 protein research in both basic and applied sciences.
