Analytical Data
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基因名
UBQLN4
- Application
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别名
UBQLN4；C1orf6；CIP75；UBIN；Ubiquilin-4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NRR5
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表达区间
1-601aa
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氨基酸序列
MAEPSGAETR PPIRVTVKTP KDKEEIVICD RASVKEFKEE ISRRFKAQQD QLVLIFAGKI LKDGDTLNQH GIKDGLTVHL VIKTPQKAQD PAAATASSPS TPDPASAPST TPASPATPAQ PSTSGSASSD AGSGSRRSSG GGPSPGAGEG SPSATASILS GFGGILGLGS LGLGSANFME LQQQMQRQLM SNPEMLSQIM ENPLVQDMMS NPDLMRHMIM ANPQMQQLME RNPEISHMLN NPELMRQTME LARNPAMMQE MMRNQDRALS NLESIPGGYN ALRRMYTDIQ EPMFSAAREQ FGNNPFSSLA GNSDSSSSQP LRTENREPLP NPWSPSPPTS QAPGSGGEGT GGSGTSQVHP TVSNPFGINA ASLGSGMFNS PEMQALLQQI SENPQLMQNV ISAPYMRSMM QTLAQNPDFA AQMMVNVPLF AGNPQLQEQL RLQLPVFLQQ MQNPESLSIL TNPRAMQALL QIQQGLQTLQ TEAPGLVPSL GSFGISRTPA PSAGSNAGST PEAPTSSPAT PATSSPTGAS SAQQQLMQQM IQLLAGSGNS QVQTPEVRFQ QQLEQLNSMG FINREANLQA LIATGGDINA AIERLLGSQL S
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分子量
63.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UBQLN4 (Ubiquilin 4) is a member of the Ubiquilin family, which plays a crucial role in the regulation of protein homeostasis, including the degradation of misfolded or damaged proteins via the ubiquitin-proteasome system. Research into UBQLN4 has gained traction due to its involvement in various cellular processes, such as proteasomal degradation, cellular stress response, and the maintaining of protein quality. Its dysregulation has been linked to several neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, making it a significant focus of medical research. UBQLN4 acts by interacting with both ubiquitin chains and proteasomes, thereby facilitating the recognition and processing of ubiquitinated substrates. Moreover, studies have indicated that UBQLN4 may also participate in key signaling pathways that modulate cellular responses to stress. Given its importance in maintaining proteostasis and its potential implications in disease, the characterization of recombinant UBQLN4 proteins presents an opportunity to explore its functional mechanisms in greater detail, investigate its interactions with other cellular components, and evaluate its therapeutic potential. The development of high-purity, functionally active UBQLN4 recombinant proteins is essential for these studies, paving the way for new insights into its role in health and disease. Ultimately, elucidating the biological functions of UBQLN4 through comprehensive biochemical and cellular assays could contribute to a better understanding of its role in protein regulation and its impact on neurodegeneration, potentially leading to novel therapeutic strategies.
