Analytical Data
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Gene name
PEX7
- Application
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Alternative Names
PBD9B; PCDP1; Peroxin 7; Peroxin-7; Peroxisomal PTS2 receptor; Peroxisomal targeting signal 2 receptor; Peroxisome biogenesis factor 7; Peroxisome targeting signal 2 receptor; PEX7; PEX7 protein; PEX7_HUMAN; PTS2 receptor; PTS2R; RCDP1; RD
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00628
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Expression Region
1-323 aa
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AA Sequence
MSAVCGGAAR MLRTPGRHGY AAEFSPYLPG RLACATAQHY GIAGCGTLLI LDPDEAGLRL FRSFDWNDGL FDVTWSENNE HVLITCSGDG SLQLWDTAKA AGPLQVYKEH AQEVYSVDWS QTRGEQLVVS GSWDQTVKLW DPTVGKSLCT FRGHESIIYS TIWSPHIPGC FASASGDQTL RIWDVKAAGV RIVIPAHQAE ILSCDWCKYN ENLLVTGAVD CSLRGWDLRN VRQPVFELLG HTYAIRRVKF SPFHASVLAS CSYDFTVRFW NFSKPDSLLE TVEHHTEFTC GLDFSLQSPT QVADCSWDET IKIYDPACLT IPA
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Molecular Weight
35.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PEX7 is a pivotal protein involved in the peroxisomal biogenesis process, specifically recognized for its role as a receptor for the import of peroxisomal matrix proteins. Research into PEX7 and its function is critical because defects in this pathway can lead to various peroxisomal disorders, such as Zellweger syndrome and other related conditions, which are characterized by the improper functioning of peroxisomes and can result in severe developmental and metabolic consequences. The study of PEX7 is further fueled by the need to understand the molecular mechanisms underlying peroxisomal protein import, as well as the potential for therapeutic interventions in diseases caused by PEX7 deficiencies. Recent advancements in structural biology and biochemistry techniques have allowed researchers to elucidate the molecular interactions between PEX7 and its ligands, enhancing our understanding of the import mechanism and identifying potential targets for drug development. Understanding PEX7's structure and function may also shed light on its evolutionary significance across different species, thereby contributing to the broader field of cell biology and organelle function. Overall, PEX7 represents a crucial focus of research that bridges basic science and clinical implications, aiming to clarify its multifaceted roles in cellular physiology and its potential impact on treating peroxisomal disorders.
